Laboratoire en 1ère ligne contre les maladies neurologiques

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Communiqués de presse

> Communiqués de presse

11 janvier 2018 - Theranexus annonce la délivrance en Europe du brevet couvrant son candidat médicament THN102 pour le traitement de la narcolepsie et de la maladie de Parkinson 

11 janvier 2018 - Theranexus annonce la délivrance en Europe du brevet couvrant son candidat médicament THN102 pour le traitement de la narcolepsie et de la maladie de Parkinson


Lyon, le 11 janvier 2018 – THERANEXUS, société biopharmaceutique innovante dans le traitement des maladies neurologiques, annonce aujourd’hui la délivrance d’un brevet européen pour son candidat médicament THN102, notamment dans le traitement de la narcolepsie et de la somnolence diurne excessive dans la maladie de Parkinson. Ce brevet a été octroyé le 3 janvier 2018 au Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA) par l’Office Européen des Brevets (OEB). Theranexus jouit d’une licence exclusive mondiale sur ce brevet.

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21 septembre 2017 - Theranexus annonce la délivrance aux Etats-Unis du brevet couvrant son candidat médicament THN102 pour le traitement de la narcolepsie et de la maladie de Parkinson 

21 septembre 2017 - Theranexus annonce la délivrance aux Etats-Unis du brevet couvrant son candidat médicament THN102 pour le traitement de la narcolepsie et de la maladie de Parkinson


Lyon, le 21 septembre 2017 - Theranexus, société biopharmaceutique innovante dans le traitement des maladies du système nerveux central, annonce aujourd’hui la délivrance du brevet américain n° US 9,750,734.

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14 septembre 2017 - Theranexus renforce son équipe de management avec l'arrivée de Thierry Lambert en tant que directeur financier 

14 septembre 2017 - Theranexus renforce son équipe de management avec l'arrivée de Thierry Lambert en tant que directeur financier


Lyon, le 14 septembre 2017 - Theranexus, une société biopharmaceutique innovante dans le traitement des maladies du système nerveux central, annonce le renforcement de son équipe dirigeante avec la nomination de Thierry Lambert en qualité de directeur financier.

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29 août 2017 - Theranexus annonce la nomination de Werner Rein en tant que directeur médical 

29 août 2017 - Theranexus annonce la nomination de Werner Rein en tant que directeur médical


Lyon, le 29 août 2017 – Theranexus, une société biopharmaceutique innovante dans le traitement des maladies du système nerveux central, étoffe son équipe dirigeante avec la nomination de Werner Rein au poste de directeur médical.

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18 juillet 2017 - Theranexus annonce la publication d'un article scientifique évaluant le rôle des cellules non neuronales dans le traitement du système nerveux central 

18 juillet 2017 - Theranexus annonce la publication d'un article scientifique évaluant le rôle des cellules non neuronales dans le traitement du système nerveux central


La société présentera aussi les premières données de son candidat médicament THN102 à l’International Gap Junction Conference (IGJC) qui aura lieu à Glasgow du 29 Juillet au 2 Août 2017

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October 27th, 2016 - Inclusion of the first patient in the phase II clinical study that aims to test THN102 in patients affected by narcolepsy 

October 27th, 2016 - Inclusion of the first patient in the phase II clinical study that aims to test THN102 in patients affected by narcolepsy


Lyon, October 27th, 2016 - Theranexus, a clinical-stage biopharmaceutical company, announced today that the first patient has been recruited in the study entitled “safety and efficacy of THN102 on sleepiness in narcolepsy patients” (NCT02821715), a phase II clinical study evaluating the efficacy and tolerance of THN102 in the treatment of excessive daytime sleepiness associated with narcolepsy in adult patients.

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October 4th, 2016 - Theranexus has obtained an orphan drug designation from the FDA for THN102 in the treatment of narcolepsy 

October 4th, 2016 - Theranexus has obtained an orphan drug designation from the FDA for THN102 in the treatment of narcolepsy


Lyon, October 4th 2016 - Theranexus, a clinical-stage biopharmaceutical company, announced today that it's most advanced drug candidate, THN102, has received an Orphan Drug Designation (ODD) from the American regulatory agency, the FDA, for the treatment of narcolepsy, a rare and highly debilitating sleep/wake disorder.

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September 20th, 2016 - Theranexus and its partners receive support from the FUI (French Inter-ministry Fund) for their project, Cx-COG 

September 20th, 2016 - Theranexus and its partners receive support from the FUI (French Inter-ministry Fund) for their project, Cx-COG


Lyon, 20th of September 2016 – Theranexus, a clinical-stage biopharmaceutical company, has announced today that it has received funding from the FUI (French Inter-ministry Fund) for its project CX-COG (FUI AAP22) which has been approved by the competitiveness clusters Lyonbiopôle and Atlanpôle Biothérapies. This project, which will be carried out in collaboration with the team of Prof. Régis Bordet (Lille University, Lille University Hospital, Inserm) and the company Synerlab, concerns the pharmaceutical formulation development and clinical validation of the efficacy of product THN201 in the treatment of neurocognitive impairment particularly associated with Alzheimer’s disease.

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May 17th, 2016 - Theranexus reaches its primary endpoint in the proof of concept trial of THN102 in Excessive Daytime Sleepiness (EDS) 

May 17th, 2016 - Theranexus reaches its primary endpoint in the proof of concept trial of THN102 in Excessive Daytime Sleepiness (EDS)


Lyon, May 17th 2016 –Theranexus, a clinical-stage biopharmaceutical company, announced today top-line results from its proof of concept clinical trial in Excessive Daytime Sleepiness (EDS) induced by sleep deprivation in healthy volunteers. Those results show a beneficial effect of THN102 (combination of modafinil and flecainide, repurposed at low dose as glial connexin modulator) on outcomes measuring vigilance and cognition throughout the sleep deprivation and when compared to the standard of care modafinil.

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March 30th, 2016 - Preclinical results published in the specialist medical journal Sleep, Phase II entry of THN102 

March 30th, 2016 - Preclinical results published in the specialist medical journal Sleep, Phase II entry of THN102


Paris, March 30th 2016 -Theranexus, a biopharmaceutical company already in the clinical trial stages of its lead project, has announced the publication of an article in Sleep, a peer-reviewed journal and a recognised international reference point for research into sleep disorders.

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October 19th, 2015 - Inclusion of the first subjects in the efficacy study on the treatment of sleep disorders 

October 19th, 2015 - Inclusion of the first subjects in the efficacy study on the treatment of sleep disorders


Paris, 19th October 2015 – Biotechnology company Theranexus-founded by Franck Mouthon, CEO, and Mathieu Charvériat, Scientific Director-is pleased to announce the launch of the clinical efficacy phase of its lead program, THN102, in the treatment of sleep disorders.

Based on the positive results obtained in phase I, which focused on the safety of THN102, Theranexus was granted authorisation to assess the efficacy of the product. Coordinated by IRBA's Fatigue and Vigilance unit headed by Mounir Chennaoui and backed by the French Army's Central Pharmacy for the manufacture and release of experimental medication, the Phase-Ib study is being conducted at the Percy Military Hospital (HIA) in Clamart near Paris. Head doctor, Fabien Sauvet, a sleep specialist from the IRBA, is managing the double-blind trial with placebo, active comparator and the product THN102 being administered in three doses to sleep-deprived volunteers. The trial is designed to assess the capacity of THN102, in particular, to keep subjects awake and maintaining their level of cognitive performance (attention, memory). The study has the financial backing of the French Defence Procurement and Technology Agency (DGA) in the framework of the government's “RAPID” program that supports defence-sector R&D projects.

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July 15th, 2015 - Success of phase 1 trial on the safety of a new treatment of narcolepsy and launch of efficacy studies 

July 15th, 2015 - Success of phase 1 trial on the safety of a new treatment of narcolepsy and launch of efficacy studies


Paris, July 15, 2015 - Created by Franck Mouthon, CEO, and Mathieu Charvériat, CSO, the biotechnology company Theranexus has announced positive results in phase 1 of its first program in the treatment of narcolepsy referred to as THN102, as well as the launch of efficacy studies.

Theranexus, a CEA spin-off, designs and develops drug combinations to improve the efficacy and safety of certain neurological and psychiatric treatments.

Bolstered by the €3.6 million raised for the THN102 program, Theranexus aims to treat narcolepsy, a disabling orphan disease chronically affecting sleep-wake cycles.
This program is based on the combination of a reference psychostimulant and a small molecule repositioned at a low dose as modulator of specific connexins in the central nervous system.

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November 17th, 2014 - Theranexus lève avec succès 3,6 M€ en amorçage 

November 17th, 2014 - Theranexus lève avec succès 3,6 M€ en amorçage


Theranexus, société essaimée du CEA annonce la réalisation d’une levée de fonds pour un montant global de 3,6 M€ auprès d’Auriga Partners, de CEA Investissement (via son fonds Amorçage Technologique Investissement), d’Emergence Innovation 1, géré par Sofimac Partners, et de Rhône-Alpes Création.

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